Thursday, February 12, 2015

Live for ever: Scientists say they’ll soon extend life ‘well beyond 120’

Live for ever: Scientists say they’ll soon extend life ‘well beyond 120’
Fixing the ‘problem’ of ageing is the mission of Silicon Valley, where billions is pouring into biotech firms working to ‘hack the code’ of life – despite concerns about the social implications
 ZoĆ« Corbyn  11 Jan 2015 
In Palo Alto in the heart of Silicon Valley, hedge fund manager Joon Yun is doing a back-of-the-envelope calculation. According to US social security data, he says, the probability of a 25-year-old dying before their 26th birthday is 0.1%. If we could keep that risk constant throughout life instead of it rising due to age-related disease, the average person would – statistically speaking – live 1,000 years. Yun finds the prospect tantalising and even believable. Late last year he launched a $1m prize challenging scientists to “hack the code of life” and push human lifespan past its apparent maximum of about 120 years (the longest known/confirmed lifespan was 122 years).
Yun believes it is possible to “solve ageing” and get people to live, healthily, more or less indefinitely. His Palo Alto Longevity Prize, which 15 scientific teams have so far entered, will be awarded in the first instance for restoring vitality and extending lifespan in mice by 50%. But Yun has deep pockets and expects to put up more money for progressively greater feats. He says this is a moral rather than personal quest. Our lives and society are troubled by growing numbers of loved ones lost to age-related disease and suffering extended periods of decrepitude, which is costing economies. Yun has an impressive list of nearly 50 advisers, including scientists from some of America’s top universities.   Yun’s quest – a modern version of the age old dream of tapping the fountain of youth – is emblematic of the current enthusiasm to disrupt death sweeping Silicon Valley. Billionaires and cos are bullish about what they can achieve. In Sept 2013 Google announced the creation of Calico, short for the California Life Co. Its mission is to reverse engineer the biology that controls lifespan and “devise interventions that enable people to lead longer and healthier lives”. Though much mystery surrounds the new biotech co, it seems to be looking in part to develop age-defying drugs. In April 2014 it recruited Cynthia Kenyon, a scientist acclaimed for work that included genetically engineering roundworms to live up to six times longer than normal, and who has spoken of dreaming of applying her discoveries to people. “Calico has the money to do almost anything it wants,” says Tom Johnson, an earlier pioneer of the field now at the Univ of Colorado who was the first to find a genetic effect on longevity in a worm.
In March 2014, pioneering American biologist and technologist Craig Venter – along with the tech entrepreneur founder of the X Prize Foundation, Peter Diamandis – announced a new co called Human Longevity Inc. It isn’t aimed at developing anti-ageing drugs or competing with Calico, says Venter. But it plans to create a giant database of 1 million human genome sequences by 2020, including from supercentenarians. Venter says that data should shed important new light on what makes for a longer, healthier life, and expects others working on life extension to use his database. “Our approach can help Calico immensely and if their approach is successful it can help me live longer,” explains Venter. “We hope to be the reference centre at the middle of everything.”
In an office not far from Google’s headquarters in Mountain View, with a beard reaching almost to his navel, Aubrey de Grey is enjoying the new buzz about defeating ageing. For more than a decade, he has been on a crusade to inspire the world to embark on a scientific quest to eliminate ageing and extend healthy lifespan indefinitely (he is on the Palo Alto Longevity Prize board). It is a difficult job because he considers the world to be in a “pro-ageing trance”, happy to accept that ageing is unavoidable, when the reality is that it’s simply a “medical problem” that science can solve. Just as a vintage car can be kept in good condition indefinitely with periodic preventative maintenance, so there is no reason why, in principle, the same can’t be true of the human body, thinks de Grey. We are, after all, biological machines, he says.  His claims about the possibilities (he has said the first person who will live to 1,000 years is probably already alive), and some unconventional and unproven ideas about the science behind ageing, have long made de Grey unpopular with mainstream academics studying ageing. But the appearance of Calico and others suggests the world might be coming around to his side, he says. “There is an increasing number of people realising that the concept of anti-ageing medicine that actually works is going to be the biggest industry that ever existed by some huge margin and that it just might be foreseeable.”
Since 2009, de Grey has been chief scientific officer at his own charity, theStrategies for Engineered Negligible Senescence (Sens) Research Foundation. Including an annual contribution (about $600,000 a year) from Peter Thiel, a billionaire Silicon Valley venture capitalist, and money from his own inheritance, he funds about $5m of research annually. Some is done in-house, the rest sponsored at outside institutions. (Even his critics say he funds some good science.)

Aubrey de Grey is chief scientific officer of his own charity, the Strategies for Engineered Negligible Senescence (Sens) Research Foundation. He funds about $5m of research annually. De Grey isn’t the only one who sees a new flowering of anti-ageing research. “Radical life extension isn’t consigned to the realm of cranks and science fiction writers any more,” says David Masci, a researcher at the Pew Research Centre, who recently wrote a report on the topic looking at the scientific and ethical dimensions of radical life extension. “Serious people are doing research in this area and serious thinkers are thinking about this .”
Although funding pledges have been low compared to early hopes, billionaires – not just from the technology industry – have long supported research into the biology of ageing. Yet it has mostly been aimed at extending “healthspan”, the years in which you are free of frailty or disease, rather than lifespan, although an obvious effect is that it would also be extended (healthy people after all live longer).
“If a consequence of increasing health is that life is extended, that’s a good thing, but the most important part is keeping people healthy as long as possible,” says Kevin Lee, a director of the Ellison Medical Foundation, founded in 1997 by tech billionaire Larry Ellison, and which has been the field’s largest private funder, spending $45m annually. (The Paul F Glenn Foundation for Medical Research is another.) Whereas much biomedical research concentrates on trying to cure individual diseases, say cancer, scientists in this small field hunt something larger. They investigate the details of the ageing process with a view to finding ways to prevent it at its root, thereby fending off the whole slew of diseases that come along with ageing. Life expectancy has risen in developed countries from about 47 in 1900 to about 80 today, largely due to advances in curing childhood diseases. But those longer lives come with their share of misery. Age-related chronic diseases such as heart disease, cancer, stroke and Alzheimer’s are more prevalent than ever.
The standard medical approach – curing one disease at a time – only makes that worse, says Jay Olshansky, a sociologist at the Univ of Chicago School of Public Health who runs a project called the Longevity Dividend Initiative, which makes the case for funding ageing research to increase healthspan on health and economic grounds. “I would like to see a cure for heart disease or cancer,” he says. “But it would lead to a dramatic escalation in the prevalence of Alzheimer’s disease.”
American biologist and technologist Craig Venter whose company Human Longevity Inc plans to create a database of a million human genome sequences by 2020. 
By tackling ageing at the root they could be dealt with as one, reducing frailty and disability by lowering all age-related disease risks simultaneously, says Olshansky. Evidence is now building that this bolder, age-delaying approach could work. Scientists have already successfully intervened in ageing in a variety of animal species and researchers say there is reason to believe it could be achieved in people. “We have really turned a corner,” says Brian Kennedy, director of the Buck Institute for Research on Ageing, adding that five years ago the scientific consensus was that ageing research was interesting but unlikely to lead to anything practical. “We’re now at the point where it’s easy to extend the lifespan of a mouse. That’s not the question any more, it’s can we do this in humans? And I don’t see any reason why we can’t,” says David Sinclair, a researcher based at Harvard.
Reason for optimism comes after several different approaches have yielded promising results. Some existing drugs, such as the diabetes drug metformin, have serendipitously turned out to display age-defying effects, for example. Several drugs are in development that mimic the mechanisms that cause lab animals fed carefully calorie-restricted diets to live longer. Others copy the effects of genes that occur in long-lived people. One drug already in clinical trials is rapamycin, which is normally used to aid organ transplants and treat rare cancers. It has been shown to extend the life of mice by 25%, the greatest achieved so far with a drug, and protect them against diseases of ageing including cancer and neurodegeneration.
A recent clinical trial by Novartis, in healthy elderly volunteers in Australia and New Zealand, found a variant of the drug enhanced their response to flu vaccine by 20% – our immunity to flu being something that declines with old age.  “[This was] the first [trial] to take a drug suspected to slow ageing, and examine whether it slows or reverses a property of ageing in older, healthy individuals,” says Kennedy. Other drugs set to be tested in humans are compounds inspired by resveratrol, a compound found in red wine. Some scientists believe it is behind the “French paradox” that French people have a low incidence of heart disease despite eating comparatively rich diets. 
In 2003, Sinclair published evidence that high doses of resveratrol extend the healthy lives of yeast cells. After Sirtris, a co co-founded by Sinclair, showed that resveratrol-inspired compounds had favourable effects in mice, it was bought by drug giant GlaxoSmithKline for $720m in 2008. Although development has proved more complicated than first thought, GSK is planning a large clinical trial this year, says Sinclair. He is now working on another drug that has a different way of activating the same pathway.
One of the more unusual approaches being tested is using blood from the young to reinvigorate the old. The idea was borne out in experiments which showed blood plasma from young mice restored mental capabilities of old mice. A human trial under way is testing whether Alzhemier’s patients who receive blood transfusions from young people experience a similar effect. Tony Wyss-Coray, a researcher at Stanford leading the work, says that if it works he hopes to isolate factors in the blood that drive the effect and then try to make a drug that does a similar thing. (Since publishing his work in mice, many “healthy, very rich people” have contacted Wyss-Coray wondering if it might help them live longer.)
James Kirkland, a researcher who studies ageing at the Mayo Clinic, says he knows of about 20 drugs now – more than six of which had been written up in scientific journals – that extended the lifespan or healthspan of mice. The aim is to begin tests in humans, but clinical studies of ageing are difficult because of the length of our lives, though there are ways around this such as testing the drugs against single conditions in elderly patients and looking for signs of improvements in other conditions at the same time. Quite what the first drug will be, and what it will do, is unclear. Ideally, you might take a single pill that would delay ageing in every part of your body. But Kennedy notes that in mice treated with rapamycin, some age-related effects, such as cataracts, don’t slow down. “I don’t know any one drug is going to do everything,” he says. As to when you might begin treatment, Kennedy imagines that in future you could start treatment sometime between the age of 40 and 50 “because it keeps you healthy 10 years longer”.
With treatments at such an early stage, guesses as to when they might arrive or how far they will stretch human longevity can only be that. Many researchers refuse to speculate. But Kirkland says the informal ambition in his field is to increase healthspan by two to three years in the next decade or more. (The EU has an official goal of adding two years to healthspan by 2020). Beyond that, what effects these drugs might have on extending our healthy lives is even harder to predict. A recent report by UK Human Longevity Panel, a body of scientists convened by insurer Legal and General, based on interviews with leading figures in the field, said: “There was disagreement about how far the maximum lifespan could increase, with some experts believing that there was a maximum threshold that could not be stretched much more than the current 120 years or so, and others believing that there was no limit.”
Nir Barzilai, director of the Institute for Ageing Research at the Albert Einstein College of Medicine, is one of the pessimists. “Based on the biology that we know today, somewhere between 100 and 120 there is a roof in play and I challenge if we can get beyond it.” Venter is one of the optimists. “I don’t see any absolute biological limit on human age,” he says, arguing that cellular immortality – in effect running the clock backwards – should be possible. “We can expect biological processes to eventually get rid of years. Whether this will happen this century or not, I can’t tell you”. Such ideas are just speculation for now. But John Troyer, who studies death and technology at the Centre for Death and Society at the University of Bath, says we need to take them seriously. “You want to think about it now before you are in the middle of an enormous mess.”
What happens if we all live to 100, 110, 120 or beyond? Society will start to look very different. “People working and living longer might make it more difficult for a new generation to get into the labour force or find houses,” says Troyer. And, with ageing delayed, how many children are we talking about as being a normal family? “There is a very strong likelihood there would be an impact on things like family structures.” A 2003 American president’s Council on Bioethics report looked at some of these issues suggesting there may be repercussions for individual psychology, too. 
One of the “virtues of mortality” it pointed out is that it may instill a desire to make each day count. Would knowing you had longer to live decrease your willingness to make the most of life? De Grey acknowledges potential practical challenges but cheerily says society would adapt, for example by having fewer children, and with people able to decide when to end their lives. There are pressing questions too about who would benefit if and when these interventions become available. Will it just be the super rich or will market incentives – who wouldn’t want it? – push costs down and make treatment affordable? 
Will Britain’s NHS or health insurers in other countries pay for drugs that extend peoples lives? The medical cost of caring for people in their twilight years would fall if they remained healthier longer, but delayed ageing will also mean more people draw pensions and state benefits. But advocates say these challenges don’t negate the moral imperative. If the period of healthy life can be extended, then doing so is the humanitarian thing to do, says Nick Bostrom, director of Oxford’s Future of Humanity Institute. “There seems to be no moral argument not to,” he says. Troyer agrees but asks whether living longer does necessarily mean you will be healthier – what does “healthy” or “healthier” mean in this context? he asks.
The far future aside, there are challenges for the new tech entrants. Calico may get too side-tracked by basic research, worries de Grey; Venter’s approach may take years to bear fruit because of issues about data gathering, thinks Barzilai; while the money on offer from the Palo Alto prize is a paltry sum for the demanded outcome and potential societal impact, says Johnson. Still, history reminds us, even if they don’t succeed, we may still benefit.
Aviator Charles Lindbergh tried to cheat death by devising ways to replace human organs with machines. He didn’t succeed, but one of his contraptions did develop into the heart-lung machine so crucial for open-heart surgery. In the quest to defeat ageing, even the fruits of failure may be bountiful.
Tech billionaires who want to make death an elective
Why might tech zillionaires choose to fund life extension research? Three reasons reckons Patrick McCray, a historian of modern technology at the University of California, Santa Barbara. First, if you had that much money wouldn’t you want to live longer to enjoy it? Then there is money to be made in them there hills. But last, and what he thinks is the heart of the matter, is ideology. If your business and social world is oriented around the premise of “disruptive technologies”, what could be more disruptive than slowing down or “defeating” ageing? “Coupled to this is the idea that if you have made your billions in an industrial sector that is based on precise careful control of 0s and 1s, why not imagine you could extend this to the control of atoms and molecules?,” he says.
Peter Thiel
Peter Thiel, 47, PayPal co-founder and Facebook’s first investor, recently told Bloomberg Television he took human growth hormone (HGH) as part of his regime to reach 120 (there is no evidence it works and it can even cause harm). He also follows a Paleo diet, doesn’t eat sugar, drinks red wine and runs regularly. He has given more than $6m to Aubrey de Grey’s Sens Foundation, dedicated to extending the human lifespan. In a recent interview he identified three main ways to approach death. “You can accept it, you can deny it or you can fight it. I think our society is dominated by people who are into denial or acceptance, and I prefer to fight it.”
Sergey Brin
Google co-founder Sergey Brin, 41, is known for his love of special projects likeGoogle Glass and CEO Larry Page has credited him for helping bring its new biotech company Calico to fruition. “We’re tackling ageing, one of life’s greatest mysteries,” says the website of the research and development company launched in 2013 and which in September 2014 joined with biopharmaceutical firm AbbVie to pour up to $1.5bn into a research facility focused on fighting age-related diseases. An extra reason for Brin’s interest may be that he discovered in 2008 he carries a genetic mutation that gives him a greater likelihood of developing Parkinson’s disease. Bryn’s wife is co-founder of personal genomics company 23andMe.
Larry Ellison
Larry Ellison, co-founder of computer company Oracle, told his biographer Mark Wilson. “How can a person be there and then just vanish, just not be there?” Ellison, 70, created the the Ellison Medical Foundation in 1997 to support ageing research and has spent more than $335m in the area, though it announced in 2013 that it would no longer fund further grants in the area. Ellison remains tight lipped about why, but there are reports that, with the emergence of Calico, he felt that he’d done his bit.
Craig Venter
“A lot of people spend their last decade of their lives in pain and misery combating disease,” says Craig Venter, San Diego based pioneering biologist and billionaire entrepreneur who raced to sequence the human genome. “I think it is possible to begin to do more about that than we are doing.” Venter, 68, announced his new company, Human Longevity, to promote healthy ageing using advances in genomics and stem cell therapies in March 2014. Would Venter like to beat death? “I am not sure our brains and our psychologies are ready for immortality,” he says. “[But] if I can count on living to 100 without major debilitating diseases I would accept that Faustian bargain right now.”
Dmitry Itskov
A digital copy of your brain turned into a low-cost, lifelike avatar, which doesn’t age. That’s the vision of Dmitry Itskov, a thirtysomething Russian multi-millionaire internet mogul who founded an online media company New Media Stars. His 2045 Initiative, so-called for the year he hopes to complete it, aims to “create technologies enabling the transfer of a individual’s personality to a more advanced non-biological carrier, and extending life, including to the point of immortality”. Though not from Silicon Valley himself, his ideas draw on those of Ray Kurzweil, a prominent futurist, who is director of engineering at Google. Kurzweil has predicted that scientists will one day find a way to download human consciousness, no longer necessitating the need for our bodies.

Thursday, February 5, 2015

Hospitals Tout Benefits Hyperbaric Oxygen Therapy - WHY not YOUR own Lungs for free

Hospitals Tout Benefits of  Hyperbaric Oxygen Therapy
It used to be associated with treating "the bends," but breathing pure oxygen can promote healing in other ways as well.
GREAT, Don Porter TOUTS teaching your LUNGS to be more efficient in assimilating MORE oxygen - PERMANENTLY - into your body FOR LIFE !  AT NO COST !
Hyperbaric oxygen treatment can help heal traumatic injuries.
By Magaly Olivero Oct. 6, 2014 |  
At first glance, the room resembles a scene from a science fiction movie: People lying in cylindrical chambers breathing 100 percent oxygen to boost the body’s natural healing process and promote the growth of new blood vessels in areas ravaged by disease.
It’s actually a scene being replicated at hospitals across the country as more Americans turn to hyperbaric oxygen therapy to treat serious conditions, such as chronic wounds, diabetic foot ulcers, radiation injury, bone infections, burns, carbon monoxide poisoning, compromised skin grafts and more.
“Hyperbaric medicine is an incredibly powerful tool. It can be as helpful and therapeutic as a surgical scalpel in the right patient for the right indication. We’re seeing a rise in specialized wound and hyperbaric centers across the United States,” says Dr. Jeffrey Niezgoda, president of the American College of Hyperbaric Medicine.
Nationwide, an estimated 1,800 to 2,000 hospitals offer hyperbaric oxygen therapy and about 500 to 700 non-hospital based programs offer the treatment, said John Peters, executive director of the Undersea and Hyperbaric Medicine Association. Almost all hospital-based programs strictly treat “indications that have been scientifically validated” by the U.S. Food and Drug Administration and UHMS, he says. Non-hospital based hyperbaric oxygen programs are more likely to offer “off-label” treatments.
Boosting oxygen levels
For decades, many people have associated hyperbaric medicine with the treatment of decompression sickness, known as “the bends,” that can strike divers who surface too quickly.
Today, hyperbaric oxygen therapy is a mainstream treatment administered in pressurized mono (single person) or multiplace chambers that can hold a dozen or more people. Patients breathe pure 100 percent oxygen under atmospheric pressure up to three times higher than normal, which significantly boosts the amount of oxygen in the blood stream. The oxygen-rich blood bathes damaged tissue, stimulating the release of chemicals that promote healing, including the formation of new blood vessels, experts say.
“We’re seeing a growing need for hyperbaric oxygen therapy services in the community,” says Peters. “We’re an aging society and with that come significant challenges to healing.”
But not all patients qualify for hyperbaric oxygen therapy and some experts caution consumers to only seek treatment for the 13 FDA-approved conditions: air or gas embolism, carbon monoxide poisoning, gas gangrene, crush injury, decompression sickness, arterial insufficiencies, severe anemia, intracranial abscesses, necrotizing (dying) soft tissue infections, osteomyelitis or chronic bone infections, delayed radiation injury, compromised skin grafts and flaps and acute thermal burn injury. 
“Hyperbaric oxygen therapy is not the magic bullet,” says Dr. Timothy Manoni, medical director of the Wound Care and Hyperbaric Center at Stamford Hospital in Connecticut. He sayssome patients mistakenly believe that hyperbaric oxygen therapy can cure cancer, Parkinson’s disease, Alzheimer’s disease and other conditions. “These are non-evidence based uses for hyperbaric oxygen therapy.”
Treating radiation damage
People with chronic bone and soft tissue damage caused by radiation to treat cancer represent a large portion of the patients seeking help at the Hyperbaric Medicine Center at the Beaumont Health System in Michigan, says Dr. Farris Gulli, its medical director. The center’s hyperbaric chamber fits up to a dozen people.
“Radiation therapy does a very good thing – it kills cancer cells. But it also damages the tiny blood vessels that feed the cells,” says Gulli. “About five to 15 percent of cancer patients can experience chronic complications from radiation therapy.”
Breast cancer survivors, for example, can develop severe chest wounds. Patients with head and neck cancers who received high doses of radiation to the jawbone risk bone damage. People treated with radiation to the pelvic area can experience bladder problems.
"In these cases, the lining of the bladder becomes damaged because of the lack of blood flow. The damage can lead to blood in the urine which could require blood transfusions," explains Gulli. “But with hyperbaric oxygen therapy, we grow new capillaries and the bleeding stops in a significant portion of our patients."
Salvaging limbs
For people with diabetes who have advanced foot ulcers, hyperbaric oxygen therapy can “mean the difference between being able to walk and being disabled for the rest of their life,” says Dr. Anna Flattau, medical director of the Hyperbaric Medicine Program at Montefiore Medical Center in New York.
Poor blood circulation and nerve damage put people with diabetes at risk of developing foot ulcers that can become seriously infected and lead to amputation. About 60 percent of non-traumatic lower limb amputations occur in adults with diabetes, according to the U.S. Centers for Disease Control and Prevention.
Montefiore focuses on preventing diabetes and keeping people with diabetes healthy, says Flattau. But if complications such as advanced foot ulcers arise, hyperbaric oxygen therapy administered in conjunction with antibiotics and other interventions may be warranted.
“It makes a huge difference in the lives of patients,” she says. “The goal is to reduce amputations in our community.”
Controversial “off label” uses
The use of hyperbaric oxygen therapy to treat “off label” conditions that haven’t been approved by the FDA – such as traumatic brain injury, autism, stroke, Parkinson’s disease, cerebral palsy, multiple sclerosis, Alzheimer’s disease and more – remains controversial. Many experts say patients should only receive off-label treatments if they are participating in a research study.
But Dr. Carol Henricks, a neurologist at Northstar Hyperbaric in Arizona, calls the FDA’s narrow focus a “terrible shame.” She believes the nation “could dramatically reduce pain and suffering if we used hyperbaric oxygen therapy to its true potential.” The International Hyperbaric Medical Association, for example, recognizes the use of hyperbaric oxygen therapy for neurological conditions. These days, Henricks’ "biggest focus" is treating veterans suffering from “brain blast injury” as a result of being exposed to explosions. These veterans develop brain injuries and post-traumatic stress disorder with symptoms such as sleep difficulties, headaches, short-term memory loss and chronic confusion.   "The first thing to happen (after hyperbaric treatment) is that they sleep through the night for the first time since being injured," she says. "Then their headaches go away and over time they get more clear thinking."   Henricks began using hyperbaric oxygen therapy 11 years ago after hearing from European doctors about its benefits in minimizing brain damage in stroke victims. She prescribed the treatment for some of her most challenging patients and the “results were tremendous.”
“The genie was out of the bag,” she says. “There was no turning back.”
Although some studies show "very positive outcomes," the use of hyperbaric oxygen therapy to treat traumatic brain injury remains “investigational,” says Niezgoda.  Despite its potential, experts said the future of hyperbaric oxygen therapy could be tempered by government concerns about unauthorized uses of the treatment.
The Centers for Medicare and Medicaid Services (CMS) this year implemented a prior authorization program in Illinois, Michigan and New Jersey “to address growing concerns” about patients receiving non-medically necessary hyperbaric oxygen therapy. In 2000, CMS paid $14.2 million to patients who received treatment for non-covered conditions or had inadequate documentation and another $4.9 million on excessive treatments.
“We need to do a better job of policing ourselves,” says Niezgoda.

Wednesday, February 4, 2015

Widely recommended simple NATURAL methods for quality health, beating cancer and Lengthen DNA Telomeres For A Longer Life

Having spent many years researching Overall Health, Curing Cancer, and "lengthening Telomeres" here are some widely recommended logical simple methods!  13+ nutrients, below in the order that many scientific studies demonstrate that  they have an important role to play (Dr. Mercola and MANY others are copied/quoted here)    
   2-4-2015       by Don Porter
1. Vitamin D
In one study of more than 2,000 women, those with higher vitamin D levels were found to have fewer aging-related changes in their DNA, as well as lowered inflammatory responsesiii. Women with higher levels of vitamin D are more likely to have longer telomeres, and vice versa. This means that people with higher levels of vitamin D may actually age more slowly than people with lower levels of vit D. Your leukocyte telomere length (LTL) is a predictor for aging related diseases. As you age, your LTL's become shorter, but, if you suffer from chronic inflammation, your telomeres decrease in length much faster, because your body's inflammatory response accelerates leukocyte turnover. Your vit. D concentrations also decrease with age, whereas your C-reactive protein (a mediator of inflammation) increases. This inverse double-whammy increases your overall risk of developing autoimmune diseases such as multiple sclerosis, and rheumatoid arthritis. The good news is that vit D is a potent inhibitor of your body's inflammatory response, and by reducing inflammation, you diminish your turnover of leukocytes, effectively creating a positive chain reaction that can help protect you against a variety of diseases. In essence, it protects your body from the deterioration of aging. Researchers have found that subsets of leukocytes have receptors for the active form of vit D (D3), which allows the vitamin to have a direct effect on these cells. This may also explain the specific connection between vit D and autoimmune disease. The absolute best way to optimize your vit D levels would be through safe sun exposure. Many will not be able to implement this recommendation due to lifestyle constraints, but  feel I would be slanted if I did not emphasize how superior photo vit D is compared to oral. So for those who are able to find the times exposing your skin to the sun will actually produce vit D  max.
2. Astaxanthin (derived from the microalgae Haematococcus pluvialis)
In the 2009 study on multivitamin use and telomere length, longer telomeres were also associated with the use of antioxidant formulasiv. According to the authors, telomeres are particularly vulnerable to oxidative stress. Additionally, inflammation induces oxidative stress and lowers the activity of telomerase (again, that's the enzyme responsible for maintaining your telomeres). Astaxanthin has emerged as one of the most potent and beneficial antioxidants currently known, with potent anti-inflammatory and DNA-protective capabilities. Research has even shown that it can protect against DNA damage induced by gamma radiationv. It has a number of unique features that make it stand out from the crowd.  For example, it is by far the most powerful carotenoid antioxidant when it comes to free radical scavenging: astaxanthin is 65X more powerful than vitamin C, 54X more powerful than beta-carotene, and 14X more powerful than vitamin E.. It's also far more effective than other carotenoids at "singlet oxygen quenching," which is a particular type of oxidation. It is 550X more powerful than vitamin E, and 11X more powerful than beta-carotene at neutralizing singlet oxygen. Astaxanthin crosses both your blood-brain barrier AND your blood-retinal barrier (beta carotene and lycopene do not), which brings antioxidant and anti-inflammatory protection to your eyes, brain and central nervous system. Another feature that separates astaxanthin from other carotenoids is that it cannot function as a pro-oxidant. Many antioxidants will act as pro-oxidants (meaning they start to cause rather than combat oxidation) when present in your tissues in sufficient concentrations. This is why you don't want to go overboard taking too many antioxidant supplements like beta-carotene, for example. Astaxanthin, on the other hand, does not function as a pro-oxidant, even when present in high amounts, which makes it highly beneficial.  Lastly, one of its most profound features is its unique ability to protect the entire cell from damage—both the water-soluble part and the fat-soluble portion of the cell. Other antioxidants affect just one or the other. This is due to astaxanthin's unique physical characteristics that allow it to reside within the cell membrane will also protecting the inside of the cell. To learn more about astaxanthin, please listen to the following interview with Dr. Robert Corish.
3. Herbal Aloe Force   I consider this Aloe, possibly the best in the world !
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Herbal Answers Promise - We offer the Whole Truth of our Aloe processing, If Herbal Aloe Force is not all that we say it is we will offer a full manufacturers refund.
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the cells, tissues, glands, organs and all systems of the body to function asoriginally designed.
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Uniquely Pure, Safe & Effective     No damaging heat is ever used
No alcohol or any harsh solvents    Unique Herbal Delivery System
Our Bio-Protected Aloe is the extracting agent. Our unique process actually incorporates the herbs with the Aloe. This makes Herbal Aloe Force a profoundly pure and effective Herbal Delivery System.
Processed to deliver the full range of all naturally occurring constituents including the fragile enzymes and large polysaccharides (betaglucomannans)  Suggested Usage: As a Daily, Dietary Supplement:
Usage will always vary & fluctuate according to your health needs. From 1/2 to 4 oz., 2-5X day or as needed.
Refrigerate after opening Herbal Aloe Force is 96% Aloe and 4% Herbs (colloidal silver 2ppm; 0.1% mineral salt as preservative)
Important Info
If the digestive system is not working properly, it begins wrecking havoc on itself and all other systems of the body. An overworked digestive system can lead to acid production and dysfunction, as well, it can inhibit enzyme production. Scientific and clinical research has demonstrated many ways in which aloe can provide soothing comfort internally, enhance healthy functioning, acid balance, pH balance, and regenerate the tissues and organs of the gastrointestinal system.
Soothing Irritation and Inflamation
In addition to containing naturally occurring pain relieving constituents, fresh aloe vera is profoundly anti-inflammatory. Studies conducted with fresh aloe vera by Dr.Robert Davis, (as reported in his book Aloe Vera: A Scientific Approach Vantage Press 1997) demonstrate this benefit in 3 profound ways: The aloe plant contains naturally occurring plant sterols that act similarly to synthetic steroids in blocking inflammation; fresh aloe’s largest polysaccharides enhance the immune cells inflammation control mechanisms; other size polysaccharides block the inflammation repsonse directly.
Tissue Regenerating
Dr. Davis also demonstrated how aloe vera is tissue regenerating in 3 different ways. The large polysacchardes, unique to fresh, raw aloe vera, have been demonstrated to stimulate the release of growth factor by the immune cells thus stimulating new tissue production. A different size polysaccharide in aloe directly stimulates the tissue production cells to produce new tissue. And thirdly, whole aloe contains plant growth factors that act like human growth factor to stimulate the regeneration of tissue. This important property of aloe is most responsible for enhancing the body’s regeneration of the acid balancing function in the digestive system and promotion healthy lining of the gastrointestinal system.
Immune Enhancing
Dr Davis’ work (as well as others) has shown that constituents in fresh aloe can directly enhance the immune cell function up to ten times greater than normal. This helps to ‘clean up’ the digestive and elimination systems. The immune cells can now gobble up to 10 times more unwanted yeast, fungus and undigested food when enhanced by the aloe. The enhanced immune system also enhances tissue regeneration and repair where needed to restore optimum functioning. Thus, drinking aloe vera can provide these profound anti- inflammatory properties soothing irritated tissues throughout the gastrointestinal system, while providing comfort. At the same time, aloe provides properties that promote the body’s own healing. Dr. Davis comments that having something that does both these things at this same time is “awe inspiring” as all anti-inflammatory drugs also inhibit tissue regeneration.
Nutrition Absorption
Healthy tissue linings are important for proper absorption of digested nutrients. In addition to promoting healthy tissues, aloe vera is known as the most penetrating substance on earth. It catapults itself into cells 5 times more easily than water bringing nutrients into cells and encouraging the outflow of toxic waste. Dr Davis has done research demonstrating aloe’s profound penetration properties as a biological vehicle. He has shown that aloe carries other substances into cells. Thus, the aloe can help the absorption of nutrients by improving complete digestion of foods into absorbable nutrients, improving the tissues to allow for absorption.
Many alternative health practitioners have reported great success with their patients drinking aloe vera juice with every kind of digestive and gastrointestinal dysfunction from acid reflux to leaky gut to crohn's and including ulcers of all types as well as ulcerative colitis, IBS, etc. (as reported in Aloe Vera and the Human Digestive System by Dr. Lawrence Plaskett, PhD). They report increased energy, immune function, and comfort from their newly balanced and functioning digestive and elimination systems.
Financial constraints for large scale studies of natural remedies has kept aloe vera use from being widely known in the mainstream medical profession for its healing potential. In addition, in the case of aloe vera, damaging processing and compromised forms of aloe being marketed has also kept the full range of its healing properties from public awareness and usage.
A study by Dr. Jerff Bland,
The Effect of Orally Consumed Aloe Vera Juice on Gastrointestinal Function, published in Preventive Medicine, March/April 1985, demonstrated very favorable effects upon a number of gastrointestinal parameters: balance of stomach acids, pH, complete digestion and flora balance. Healthy acid production and shut down is crucial to providing the right environment in the stomach for complete digestion, especially of proteins. A healthy digestive system is also more efficient at killing bacteria as they enter the body. Aloe vera has been shown to contain many digestive enzymes as well as proteolytic enzymes (that help break down built up debris).
Aloe’s use as a natural whole, raw, alkalizing food can be a significant digestive ‘answer’ to promote healing and comfort, and to restore and maintain the proper acid, enzyme, and bacteria balance. Its many benefits as an aide for healthy functioning and complete digestion and for enhanced nutritional absorption are finally available to us.

4. Ubiquinol (CoQ10)
Coenzyme Q10 (CoQ10) is the fifth most popular supplement in the United States, taken by about 53% of Americans, according to a 2010 survey by ConsumerLab.comvii. This is a good thing as one in every four Americans over 45 is taking a statin and every single one of these individuals needs to be taking it.  CoQ10 is used by every cell in your body. In fact, it is so important for your body's daily functions that it is also known as "ubiquinone" because it's 'ubiquitous' in the human body.What you may not know, however, is that to benefit from the form of the nutrient needed to produce cellular energy and help you reduce the typical signs of aging, your body must convert the ubiquinone to the reduced form, called ubiquinol -- and research is showing that this reduced form may actually be superior for your health in a number of ways. If you're under 25 years old your body is capable of converting CoQ10 from the oxidized to the reduced form. However, if you're older, your body becomes more and more challenged to convert the oxidized CoQ10 to ubiquinol.  Premature aging is one primary side effect of having too little CoQ10 because this essential vitamin recycles other antioxidants, such as vitamin C and E. CoQ10 deficiency also accelerates DNA damage, and because CoQ10 is beneficial to heart health and muscle function this depletion leads to fatigue, muscle weakness, soreness and eventually heart failure.  In an interview with Dr. Stephen Sinatra, he recounts an experiment from the mid-90's on aging rats. The average lifespan of a rat is two years. Rats given CoQ10, at the end of their life, had more energy, better coats, and better appetites, compared to the rats that did not get CoQ10. The supplement basically had a potent anti-aging effect, in the sense it maintained youthfulness until the very end of their life. In terms of life extension, the effect was minimal. Dr. Sinatra also conducted his own research and found that CoQ10 given to both younger and older mice resulted in increased energy and vigor. Older mice traveled through mazes quicker, they had better memory, and had more locomotor activity than those who did not get CoQ10. So CoQ10 definitely appears to improve the quality of life, even if it may not significantly increase longevity per say. For more information and dosage recommendations, please see this previous CoQ10article.
5. Fermented Foods / Probiotics
It's quite clear that eating a diet consisting of high amounts of processed foods will shorten your life, yet 90 percent of the money Americans spend on food is spent on processed food, and the number one source of calories in the US comes from high fructose corn syrup – a staple ingredient in nearly all processed foods, from frozen dinners, to condiments, snacks, and soda. Researchers have even discovered that genetic mutations and malfunctions that cause disease are created in future generations when highly processed and artificial foods are consumed!  Part of the problem is that these processed, sugar- and chemical-laden foods effectively destroy your intestinal microflora. Your gut flora has incredible power over your immune system, which, of course, is your body's natural defense system. Antibiotics, stress, artificial sweeteners, chlorinated water and many other factors can also reduce the amount of probiotics (beneficial bacteria) in your gut, which can predispose you to illness and premature aging. Ideally, you'll want to make traditionally cultured and fermented foods a staple in your daily diet.   You can use a probiotic supplement, but getting your probiotics from food is definitely better as you can consume far more beneficial bacteria, in many cases up to 100X more. Fermented vegetables are an excellent alternative as they are both delicious and simple to make.
6. Krill Oil
According to Dr. William Harris, an expert on omega-3 fats, those who have an omega-3 index of less than four percent age much faster than those with indexes above eight percent. Therefore, your omega-3 index may also be an effective marker of your rate of aging. According to Dr. Harris' research, omega-3 fats appear to play a role in activating telomerase, which, again, has been shown to be able to actually reverse telomere shortening.  Although this research is preliminary, I would suggest that optimizing your omega-3 levels above 8% would be a good strategy if you're interested in delaying aging. (Your doctor can order the omega-3 index test from a lab called Health Diagnostic Laboratory in Richmond, VA.) After all, you have nothing to lose and a lot to gain by doing so, since omega-3 has proven to be extremely important for your health in so many respects.  A favorite animal-based omega-3 is krill oil, as it has a number of benefits not found in other omega-3 supplements such as fish oil. Aside from higher potential for contamination, fish oil supplements also have a higher risk of suffering oxidation damage and becoming rancid. Dr. Rudi Moerck has discussed these risks at great length in a previous interview. Krill oil also contains naturally-occurring astaxanthin, which makes it nearly 200X more resistant to oxidative damage compared to fish oil. Additionally, according to Dr. Harris' research, krill oil is also more potent gram for gram, as its absorption rate is much higher than fish oil. You get somewhere between 25- 50% more omega-3 per milligram when you take krill oil compared to fish oil, hence you don't need to take as much.
7. Vitamin K2
Vitamin K may very well be "the next vitamin D" as research continues to illuminate a growing number of benefits to your health. While most people get enough vitamin K from their diets to maintain adequate blood clotting, they're NOT enough to offer protection against more serious health problems. For ex., research over the past few years suggest that vitamin K2 can provide substantial protection from prostate cancer, which is one of the leading causes of cancer among men in the USA. And research results are similarly encouraging for the benefits of vit K to your cardiac health: In 2004, the Rotterdam Study, which was the first study demonstrating the beneficial effect of vit K2, showed that people who consume 45 mcg of K2 daily live 7 years longer than people getting 12 mcg per day.  In a subsequent study called the Prospect Studyx, 16,000 people were followed for 10 years. Researchers found that each additional 10 mcg of K2 in the diet results in 9% fewer cardiac events. K2 is present in fermented foods, particularly cheese and the Japanese food natto, which is by far the richest source of K2.
8. Magnesium
According to the featured research, magnesium also plays an important role in DNA replication, repair, and RNA synthesis, and dietary magnesium has been shown to positively correlate with increased telomere length in women. Other research has shown that long term deficiency leads to telomere shortening in rats and cell cultures. It appears the lack of magnesium ions has a negative influence on genome integrity. Insufficient amounts of magnesium also reduce your body's ability to repair damaged DNA, and can induce chromosomal abnormalities. According to the authors, it's reasonable to hypothesize that "magnesium influences telomere length by affecting DNA integrity and repair, in addition to its potential role in oxidative stress and inflammation."
9. Polyphenols
Polyphenols are potent antioxidant compounds in plant foods, many of which have been linked to anti-aging benefits and disease reduction. Here are but a few examples of these potent antioxidant compounds:
·                     Grapes (resveratrol) — Resveratrol deeply penetrates the center of your cell's nucleus, giving your DNA time to repair free radical damage. Research dating back to 2003 showed that resveratrol, a powerful polyphenol and anti-fungal chemical, was able to increase the lifespan of yeast cells. The findings showed that resveratrol could activate a gene called sirtuin1, which is also activated during calorie restriction in various species. Since then studies in nematode worms, fruit flies, fish, mice, and human cells have linked resveratrol to longer lives. Resveratrol is found in grapes, and there are numerous products on the market containing resveratrol. I recommend looking for one made from Muscadine grapes, and that uses WHOLE grape skins and seeds, as this is where many of the benefits are concentrated.
·                     Cacao — Quite a few studies have confirmed the potent antioxidant properties, and subsequent health benefits, of raw cocoa powder. Dark, organic, unprocessed chocolate has been found to benefit your glucose metabolism (diabetic control), blood pressure, and cardiovascular health.
Green tea — Polyphenols in tea, which include EGCG (epigallocatechin gallate) and many others, have been found to offer protection against many types of cancer. The polyphenols in green tea may constitute up to 30 percent of the dry leaf weight, so, when you drink a cup of green tea, you're drinking a fairly potent solution of healthy tea polyphenols. Green tea is the least processed kind of tea, so it also contains the highest amounts of EGCG of all tea varieties. Keep in mind, however, that many green teas have been oxidized, and this process may take away many of its valuable properties. The easiest sign to look for when evaluating a green tea's quality is its color: if your green tea is brown rather than green, it's likely been oxidized. A favorite of some is matcha green tea because it contains the entire ground tea leaf, and can contain over 100X the EGCG provided from regular brewed green tea.
 How Drinking Green Tea Can Kill Cancer Cells, Penn State University Study   2/3/2015
Green Tea Ingredient May Target Protein To Kill Oral Cancer Cells 
UNIVERSITY PARK, Pa. -- A compound found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone, according to Penn State food scientists. The research could lead to treatments for oral cancer, as well as other types of cancer.   Earlier studies had shown that epigallocatechin-3-gallate -- EGCG -- a compound found in green tea, killed oral cancer cells without harming normal cells, but researchers did not understand the reasons for its ability to target the cancer cells, said Joshua Lambert, associate professor of food science and co-director of Penn State's Center for Plant and Mushroom Foods for Health . The current study shows that EGCG may trigger a process in the mitochondria that leads to cell death. 
"EGCG is doing something to damage the mitochondria and that mitochondrial damage sets up a cycle causing more damage and it spirals out, until the cell undergoes programmed cell death," said Lambert. "It looks like EGCG causes the formation of reactive oxygen species in cancer cells, which damages the mitochondria, and the mitochondria responds by making more reactive oxygen species."  As this mitochondrial demise continues, the cancer cell also reduces the expression of anti-oxidant genes, further lowering its defenses. "So, it's turning off its mechanism of protection at the same time that EGCG is causing this oxidative stress," Lambert added. The EGCG did not cause this reaction in normal cells. In fact, it appeared to increase the protective capabilities of the cell, according to the researchers, who report their findings in the online issue of Molecular Nutrition and Food Research.    The researchers studied normal human oral cells side-by-side with human oral cancer cells to determine how EGCG was affecting cancer cells differently than normal cells. They grew the normal and cancer cells on petri dishes and then exposed them to EGCG, the major polyphenol found in green tea, at concentrations typically found in the saliva after chewing green-tea chewing gum. At various times, the researchers would collect the cells and check for oxidative stress and signs of antioxidant response. "We also took a lot of pictures, so we could use fluorescent dyes that measure mitochondrial function and oxidative stress and actually see these things develop," said Lambert, who worked with Jong-Yung Park, a research technician and Ling Tao, a doctoral candidate in food science.   The researchers said that a protein called sirtuin 3 -- SIRT3 -- is critical to the process. "It plays an important role in mitochondrial function and in anti-oxidant response in lots of tissues in the body, so the idea that EGCG might selectively affect the activity of sirtuin 3 in cancer cells -- to turn it off -- and in normal cells -- to turn it on -- is probably applicable in multiple kinds of cancers," Lambert said.  The study builds on earlier research on how EGCG affected oral cancer, a disease that is expected to kill more than 8,000 people in the United States this year.  "We've published one paper previously just looking at the effect of these green tea polyphenols on oral cancer cells in cultures, and there have been other papers published using oral cancer cells and at least a couple of animal model studies that have looked at oral cancer and prevention of oral cancer," said Lambert.   He said the next step would be to study the mechanism in animals. If those tests and human trials are successful, the researchers then hope to create anti-cancer treatments that are as effective as current treatments without the harmful side effects.   "The problem with a lot of chemotherapy drugs -- especially early chemotherapy drugs -- is that they really just target rapidly dividing cells, so cancer divides rapidly, but so do cells in your hair follicles and cells in your intestines, so you have a lot of side effects," said Lambert. "But you don't see these sorts of side effects with green
10. Folate (aka Vitamin B9, or Folic Acid)
According to the featured study in the Journal of Nutritional Biochemistry, plasma concentrations of the B vitamin folate correspond to telomere length in both men and women. Folate plays an important role in the maintenance of DNA integrity and DNA methylation, both of which influence the length of your telomeres. It is useful for preventing depression, seizure disorders and brain atrophy. In fact, folate deficiency can lead to elevated homocysteine levels, which can be a major contributor to heart disease and Alzheimer's disease. One unfortunate and preventable reason why some believe folate numbers are slipping is the increased prevalence of obesity, which negatively affects the way most people metabolize this important vitamin. The ideal way to raise your folate levels is to eat plenty of fresh, raw, organic leafy green vegetables, and beans. Please note that it is the natural folate from food that has been found to be beneficial. This may not be true for the supplement folic acid.
11. Vitamin B12
Vitamin B12 is fittingly known as "the energy vitamin," and your body requires it for a number of vital functions. Among them: energy production, blood formation, DNA synthesis, and myelin formation. (Myelin is insulation that protects your nerve endings and allows them to communicate with one another.) Unfortunately, research suggests about 25 percent of American adults are deficient in this vitally important nutrient, and nearly half the population has suboptimal blood levels. Vitamin B12 is found almost exclusively in animal tissues, including foods like beef and beef liver, lamb, snapper, venison, salmon, shrimp, scallops, poultry and eggs. It's not readily available in plants, so if you do not eat meat or animal products you are at risk of deficiency. The few plant foods that are sources of B12 are actually B12 analogs. An analog is a substance that blocks the uptake of true B12, so your body's need for the nutrient actually increases. If you aren't getting sufficient B12 in your diet, I recommend you begin supplementation immediately with this vital nutrient with either an under-the-tongue fine mist spray or vit B12 injections. Ensuring your body has adequate B12 can vastly improve the quality of your life and prevent debilitating, even life-threatening diseases which result from a deficiency of this all-important nutrient.
12. Curcumin (Turmeric) Theracurmin
Curcumin — the active ingredient in the spice turmeric—acts both as an immune booster and potent anti-inflammatory. But perhaps its greatest value lies in its anti-cancer potential, and it has the most evidence based literature backing up its anti-cancer claims of any other nutrient. It affects over 100 different pathways once it gets into a cell—among them, a key biological pathway needed for development of melanoma and other cancers. The spice actually stops laboratory strains of melanoma from proliferating and pushes the cancer cells to commit suicide by shutting down nuclear factor-kappa B (NF-kB), a powerful protein known to induce abnormal inflammatory response that leads to an assortment of disorders such as arthritis and cancer.To get the full benefits that curcumin has to offer, you will want to look for a turmeric extract with at least 95 percent curcuminoids that contains only 100%  certified organic ingredients. The formula should be free of fillers, additives and excipients (a substance added to the supplement as a processing or stability aid), and the manufacturer should use safe production practices at all stages: planting, cultivation, selective harvesting, and then producing and packaging the final product.  Creation of trademarked Theracurmin is IMPRESSIVE.
Theravalues: Extensive Clinical Trials Affirms the Benefits of Theracurmin™ on Diastolic Function in Hypertensive Patients
The Research Group Examines the Unprecedented Efficacy of the Newly Developed Drug
March 25, 2012  CHICAGO--(BUSINESS WIRE)--The research group led by Dr. Koji Hasegawa, Dir. of the Translational Research Div. at the National Hospital Org. Kyoto Medical Ctr and Dr. Tatsuya Morimoto, Prof. @ the Molecular Medicine School of Pharmaceutical Sciences, Univ of Shizuoka, announced today based on the recent human clinical trials, that Theracurmin™ has continuously shown positive impact on human diastolic functions. Theracurmin™ is a patented absorption-enhanced form of curcumin, developed by Theravalues Corp, a Japanese bio-venture.  “Chronic inflammation often leads to several forms of illness such as cancer, metabolic disease, neuro-cognitive diseases, and arthritis. We anticipate that Theracurmin™ will potentially alleviate these conditions.”
At the American Heart Association (AHA) Scientific Session held in Nov. 2011, the research group unveiled the results of a 24-week long human clinical trial, which affirmed Theracurmin™’s efficacy in improving the symptoms of the left ventricular diastolic failure.
“After demonstrating the positive impact of Theracurmin™ at AHA 2011, we have completed clinical trials administering Theracurmin™ for 24 weeks to another 8 participants,” said Dr. Morimoto. The analysis on the clinical trials for 38 participants conducted by the end of 2011 has been presented at the American College of Cardiology 2012. “We are very excited to discover that the result of the clinical trials underscores the effectiveness of Theracurmin™ in the improvement of the diastolic function in hypertensive patients.”   Curcumin, a polyphenol derived from turmeric (Curcuma Longa L), has anti-inflammatory and anti-oxidant therapeutic properties, which effectively treat chronic inflammatory diseases. However, its poor bioavailability due to low oral absorption has been an ongoing challenge. Theravalues’ innovative technology, which has been applied to Theracurmin™, addresses this issue by creating surface controlled colloidal dispersion, which enhances body absorption by 27 times compared to that of conventional curcumin powder
13. Vitamin A
According to the featured study in the Journal of Nutritional Biochemistry, telomere length is positively associated with dietary intake of vitamin A in women who do not take multivitaminsxiv. It plays an important role in your immune response, and if you're deficient, you become predisposed to infections that can promote telomere shortening. However, vitamin A does not appear to have a dose-dependent effect on telomere length, so you don't need high amounts.
Two Additional Lifestyle Strategies that Affect Telomere Length
While a nutritious diet accounts for about 80 percent of the benefits derived from a healthy lifestyle, exercise cannot be ignored, and there's evidence suggesting that exercise protects against telomere shortening as well. Yet another lifestyle strategy that can have a beneficial impact is intermittent fasting.
·                     Exercise — One recent study on post-menopausal women suffering from chronic stress found that "vigorous physical activity appears to protect those experiencing high stress by buffering its relationship with telomere length (TL)."  In fact, among the women who did not exercise, each unit increase in the Perceived Stress Scale was related to a 15-fold increase in the odds of having short telomeres. Those who did exercise regularly showed no correlation between telomere length and perceived stress!
High-intensity exercise appears to be the most effective all-natural approach to slow down the aging process by reducing telomere shortening. In fact, research has shown there's a direct association between reduced telomere shortening in your later years and high-intensity-type exercisesxvi: Greta Blackburn's book The Immortality Edge: Realize the Secrets of Your Telomeres for a Longer, Healthier Lifexvii further details the importance of high-intensity exercise to prevent telomere shortening.
·                     Intermittent Fasting or smaller meals — Previous research has shown that you can extend your lifespan by reducing your caloric intake, and I've written about this technique in the past. The problem is that most people do not understand how to properly cut calories, because in order to remain healthy, you have to cut out the right kind of calories—namelycarbohydrates. Research by Professor Cynthia Kenyon has shown that avoiding carbs will activate genes that govern youthfulness and longevity. But the health benefits of calorie restriction can also be achieved by intermittent fasting (keep in mind you still need to cut out sugars and grains).  
Over the past long periods MANY have tried to convince the world of a couple of radical things. Another outlook !
The three most important are:
1)      We should treat aging as a disease because it is one. Part and parcel of that is that fixing aging would save billions of research dollars in trying to “cure” heart disease, cancer, Alzheimer’s Disease etc because to me they are the symptoms of the real disease known as aging!
2)      The best way to achieve #1 is re-lengthen your telomeres to a more youthful measurement thus reversing biologic age.
3)      DIET, Ideally Organic, Get lots of Oxygen, and Healthy Alkalinity levels
Now there have been some significant previous studies on this and all of them have shown exactly that.
Jerry Shay who I mentioned in a previous blog used fetal fibroblasts and turned on telomerase in an ongoing fashion creating a cancer free immortal cell line. That was 1999.  In 2002 Walter Funk de-aged human skin grafted on to mice by turning on the telomerase in the mice. In 2010 JAMA a Journal known to be anti-alternative medicine and a stalwart of traditional allopathic medical care published a study showing the association of SHORT telomeres with increased incidence of cancer and worsening prognosis in cancer. Bottom line short telomeres area  a major risk factor for cancer! Keep your telomeres long!
In 2012 Maria Blasco set the telomere world on its ear with 2 studies. The first showed a 25% increase in life span in old mice with improved health parameters and no increases in cancer. The second used TA-65 to improve health span parameters in mice again with no increase in cancer. That same year Ron DePinho who was known not to hold much stock in telomerase therapy published a study while at Dana Farber reversing aging in mice by turning on telomerase. The mice became more sexually active and could reproduce again. Those with Alzheimers improved the measure of cognitive performance and brain function. They became stronger faster and more coordinated and all the parameters correlated with a return to a youthful appearance and biomarkers of young mice.  Critics will say that is mice and human cell lines. Human studies were published using the only really tested telomerase activator.  While it is currently very difficult to design a study showing extension of human life, 2 studies, one published in 2011 the other in 2013 showed improved biomarkers of aging and health span.
Ok back to the newest study.
Researchers at Stanford developed a mimic for the telomerase component known as hTERT (human telomerase reverse transcriptase). Using this on human skin cell lines increased the ability of these cells to replicate by 40X or in simpler terms, reversed aging by 10 years. The key thing and one thing that is shared with TA-65 is that this was an “on-off” phenomenon. This means the telomeres are lengthened in a very fast reaction and then the lengthening stops until you use it again.
So how does this compare to TA-65?
Well I published my own results after 4 years of use of High Dose TA-65. I was able to lengthen my telomeres by 1400 base pairs. Now the researchers at Standford said 1,000 base pairs equals 10 years.  That would mean I de-aged by 14 years!  I should also tell you that sadly the Standford stuff is not going to be available for human consumption at any time soon. The tell tale comment was the usual, “We hope this will lead to the development of new drugs to cure diseases”.  Yep the Big Pharma pay day is the reason we have most of these labs and the thing that most researchers wish for in their dreams.  But at least there was a passing comment on how this might affect aging.   Skeptics are going to be hard to find very soon!

While we cheer on these efforts and hope that scientists will begin to look at aging as a curable disease.  In the meantime you really only have two options: do nothing, or do all or most of the above.

Your choice,  I made mine 8 years ago when I was  diagnosed with Stage IV, Metasticised Prostate Cancer 
and given 3 years to live !